173 results found
    1. Genetics and Genomics
    2. Neuroscience

    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

    Colleen M Palmateer, Catherina Artikis ... Michelle N Arbeitman
    A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies, Kai Lei ... Alejandro Sánchez Alvarado
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.
    1. Neuroscience

    Hippocampal remapping induced by new behavior is mediated by spatial context

    Samuel J. Levy, Michael E. Hasselmo
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

    Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Real-time classification of experience-related ensemble spiking patterns for closed-loop applications

    Davide Ciliberti, Frédéric Michon, Fabian Kloosterman
    A brain–computer interface for real-time identification of transient neural activity patterns enables causal inference of the role of these patterns in cognition through closed-loop manipulation.
    1. Neuroscience

    Neurofeedback training can modulate task-relevant memory replay rate in rats

    Anna K Gillespie, Daniela Astudillo Maya ... Loren M Frank
    A neurofeedback training paradigm provides a new approach to manipulating physiologically relevant hippocampal replay.
    1. Neuroscience

    Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons

    Dongsheng Xiao, Matthieu P Vanni ... Timothy H Murphy
    Mesoscale cortical calcium activity correlating with single cortical and thalamic cell spiking reveal rich dynamics and support a novel approach for investigating in vivo functional networks in the mammalian brain.
    1. Neuroscience

    Disordered breathing in a mouse model of Dravet syndrome

    Fu-Shan Kuo, Colin M Cleary ... Daniel K Mulkey
    Expression of a Dravet syndrome-associated mutation in inhibitory neurons disrupts activity of brainstem respiratory neurons and diminishes respiratory behavior in conjunction with seizures and premature death.
    1. Cancer Biology

    Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

    James Boot, Gabriel Rosser ... Silvia Marino
    A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.

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