466 results found
    1. Physics of Living Systems

    Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

    Xuemeng Zhang et al.
    The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
  1. Living Science: The humanity of science

    Indira M Raman
    Science can provide cures and improve health, and it can also make us more humane.
    1. Cell Biology

    Philosophy of Biology: Drawing and the dynamic nature of living systems

    Gemma Anderson et al.
    Drawing may be a way to better understand a biological process and to explore and develop scientific ideas.
    1. Cell Biology
    2. Human Biology and Medicine

    Muscle Contraction: Too much of a good thing

    H Lee Sweeney
    A mutation that causes heart disease in humans increases the number of active myosin heads during contraction in the muscles of fruit flies, leading to the progressive dysfunction of the flight muscles and heart tube.
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    1. Developmental Biology
    2. Evolutionary Biology

    Evolution: How the zebrafish got its stripes

    Kelly A McGowan, Gregory S Barsh
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    1. Neuroscience

    Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

    Leanne M Holt et al.
    Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Cell Biology

    Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

    Kalyn Kono et al.
    Par-complex-dependent cell polarity can be cell-autonomously conferred to non-polar Drosophila S2 cells, unveiling temporal patterns toward the cortical localization of Par-complex aggregates that include a meshwork containing unit segments.
    1. Neuroscience

    Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

    Laura D Knogler et al.
    Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.

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