798 results found
    1. Physics of Living Systems

    Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

    Xuemeng Zhang et al.
    The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly

    Arkadi Shwartz et al.
    Actin is incorporated into the thin-filament arrays of skeletal muscle sarcomeres in discrete steps, and Fhos, the Drosophila homolog of FHOD-family formins, is an essential player in the process.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis: Stopping chromosomes from breaking bad

    Rima Sandhu, G Valentin Börner
    The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoskeleton: The mother of all actins?

    Felipe Merino, Stefan Raunser
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    1. Human Biology and Medicine

    Drug Discovery: From worms to fish to mice

    Guy M Benian, Hyojung J Choo
    An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.
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