48 results found
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
    1. Structural Biology and Molecular Biophysics

    Hsp40s play complementary roles in the prevention of tau amyloid formation

    Rose Irwin et al.
    Chaperones from different families and classes synergistically target different stages of tau aggregation, thus preventing pathological amyloid formation.
    1. Structural Biology and Molecular Biophysics

    The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

    Achinta Sannigrahi et al.
    How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
    1. Medicine
    2. Neuroscience

    PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

    Edoardo Bistaffa et al.
    The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
    1. Immunology and Inflammation
    2. Neuroscience

    Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    Alessio Vittorio Colombo et al.
    Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Therapeutic genetic variation revealed in diverse Hsp104 homologs

    Zachary M March et al.
    Exploring natural Hsp104 variation reveals unexpected tuning of a passive activity that inhibits aggregation of specific substrates to selectively counter TDP-43 or alpha-synuclein proteotoxicity connected to neurodegenerative disease.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cross-talk between individual phenol-soluble modulins in Staphylococcus aureus biofilm enables rapid and efficient amyloid formation

    Masihuz Zaman, Maria Andreasen
    Inter-molecular cross-seeding between phenol-soluble modulins facilitates rapid and efficient self-assembly in Staphylococcus aureus biofilms revealing a complex molecular interplay between distinct phenol-soluble modulins orchestrating functional amyloid formation.
    1. Neuroscience

    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

    Genjiro Suzuki et al.
    One α-synuclein strain inhibited proteasome activity and induced apparent pathologies, while the other did not, indicating a strain-dependent toxicity of α-synuclein aggregates, which support a prion-like behavior of α-synuclein.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Developmental Biology
    2. Neuroscience

    Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

    Chu Hsien Lim et al.
    An optogenetic approach has been developed to model Alzheimer's disease allowing light-induced Amyloid-β aggregation and tested in three model organisms, Drosophila, C. elegans and D. rerio.

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