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    1. Neuroscience
    2. Physics of Living Systems

    Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

    Louis Kang, Michael R DeWeese
    An experimentally supported model of grid cells naturally enables them to participate in firing sequences that encode rapid trajectories in space.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

    Joanna Krakowiak et al.
    Dynamic regulation of the heat shock response depends on a negative feedback loop in which Hsf1 activates expression of Hsp70 and Hsp70 specifically and directly represses Hsf1 transactivation.
    1. Neuroscience

    Different types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory

    Alex Tendler, Shlomo Wagner
    Variations in the frequency of theta brain waves enable a single network of brain regions to generate appropriate responses to stimuli with different kinds of emotional value.
    1. Genetics and Genomics

    Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

    Jacob M Garrigues et al.
    Helitron transposable elements, by providing high density transcription factor binding sites upstream of host genes, have diversified the heat shock response within and among Caenorhabditis species.
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser et al.
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.
    1. Plant Biology

    A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat

    Nikolai M Adamski et al.
    The development of genomic tools and publicly available resources in polyploid wheat provides a framework to understand biologically important traits in crops with large genomes.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

    Xu Zheng et al.
    Quantitative dissection of the roles of chaperone binding and phosphorylation in regulating heat shock factor 1 leads to a predictive model of the dynamics of the yeast heat shock response.
    1. Computational and Systems Biology
    2. Neuroscience

    Speech encoding by coupled cortical theta and gamma oscillations

    Alexandre Hyafil et al.
    Computational modelling shows that coupled theta and gamma oscillations in the auditory cortex can decompose speech into its syllabic constituents, and organize the neural spiking at faster timescale into a decodable format.
    1. Neuroscience

    Anxiety dissociates the adaptive functions of sensory and motor response enhancements to social threats

    Marwa El Zein et al.
    Social threats trigger enhanced neural representations within 200 milliseconds in sensory and motor systems of the human brain as a function of anxiety, highlighting its adaptive function in reacting rapidly to dangers in the environment.