3,262 results found
    1. Neuroscience

    Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

    Weijian Yang et al.
    An all-optical 3D two-photon imaging and photostimulation platform was demonstrated, with the capability to precisely stimulate a large group of cells in mice cortex in vivo with low laser power.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-dimensional electron crystallography of protein microcrystals

    Dan Shi et al.
    A new electron diffraction technique called MicroED allows protein structures to be determined from three-dimensional microcrystals.
    1. Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann et al.
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    1. Cancer Biology
    2. Physics of Living Systems

    Collective forces of tumor spheroids in three-dimensional biopolymer networks

    Christoph Mark et al.
    The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.
    1. Cell Biology
    2. Immunology and Inflammation

    Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

    Moosung Lee et al.
    Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim et al.
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
    1. Structural Biology and Molecular Biophysics

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.
    1. Developmental Biology

    Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Daniyal J Jafree et al.
    Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.
    1. Neuroscience

    The self-organization of grid cells in 3D

    Federico Stella, Alessandro Treves
    A computational model for the formation of neural networks of grid cells in virtual bats suggests that the highly ordered networks presumed to support spatial navigation in two dimensions cannot be routinely established in three-dimensional space.
    1. Neuroscience

    A principle of economy predicts the functional architecture of grid cells

    Xue-Xin Wei et al.
    Mathematical modeling suggests that grid cells in the rodent brain use fundamental principles of number theory to maximize the efficiency of spatial mapping, enabling animals to accurately encode their location with as few neurons as possible.

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