A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.

Rationalized selection of responsive TCR clones by single-cell analysis to aid in the generation of novel TCR transgenic animals.

Neurodegeneration driven by pathogenic aggregating proteins reorganizes the actin cytoskeleton, causing cellular stiffening and abolishing force generation required for endocytic events.

The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.

The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage including 3’TRAV to 5’TRAJ.

Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).

T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.