Evolutionary reduction in tissue number involves the simplification of the seaming process but not signaling during epithelial fusion.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

Bacterial ribosomal and transfer RNAs are symbiotic clues sensed by host general control nonderepressible 2 to support Drosophila systemic growth.

Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.

The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.

Fat-body-specific loss of actin isoform Act5C disrupts fat body cell growth and fat storage, lipoprotein secretion, and insulin signaling, revealing a non-canonical role for the cortical actin cytoskeleton in nutrient signaling and inter-organelle trafficking.

Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.

Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.