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Self-reactive CD4⁺ thymocytes have a broad impact on the composition of medullary thymic epithelial cell (mTEC) subsets by acting upstream of Aire⁺ mTECs, which conditions the induction of T-cell tolerance.

Deficiency of capicua, a transcription factor that suppresses autoimmunity, impairs positive and negative selection processes by attenuating TCR signaling in CD4⁺CD8⁺ double-positive thymocytes.

Thymocyte-attracting CCL21-expressing embryonic mTECs carry a developmental potential to give rise to self-antigen-displaying Aire-expressing mTECs.

Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.

Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.

Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.

Histone deacetylase 3 is required for CD4+ T cells to downregulate two cholesterol efflux transport proteins, ABCA1 and ABCG1, for successful proliferation after antigenic stimulation.

Single-cell RNA sequencing has revealed distinct subpopulations of hemocytes in fruit fly larvae.

The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses.