493 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

    Lauren M Saunders, Abhishek K Mishra ... David M Parichy
    Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
    1. Cancer Biology

    Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

    Viviana Anelli, Jacques A Villefranc ... Yariv Houvras
    Transformation mediated by oncogenic BRAF requires transcriptional activation of TWIST at the earliest stage of neoplastic transformation.
    1. Genetics and Genomics

    Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

    Yanis Zekri, Romain Guyot ... Karine Gauthier
    T3 regulates BAT thermogenesis by controlling the expression of genes involved in the management of metabolic fuels as well as tissue plasticity.
    1. Developmental Biology
    2. Ecology

    Fish larval recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos

    Guillaume Holzer, Marc Besson ... Vincent Laudet
    Coral reef fish larval recruitment is a metamorphosis that can be disturbed by reef pollutants, as it is under the influence of the environment through the direct control of thyroid hormone signaling.
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong, Mariana Beltcheva ... Thorold W Theunissen
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
    1. Genetics and Genomics
    2. Medicine

    Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

    Gustavo A Gomez, Patrick Aghajanian ... Subburaman Mohan
    Mouse molecular genetics and in vivo functional studies reveal that thyroid hormone is necessary for punctual proximal femur head development by a mechanism that differs temporally and molecularly from the secondary ossification center at the distal femur.
    1. Medicine

    Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain

    Federico Salas-Lucia, Csaba Fekete ... Antonio C Bianco
    T3 is taken up by axonal termini and is retrogradely transported into endosomal vesicles to the cell nucleus, where it regulates gene expression.
    1. Computational and Systems Biology

    Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

    Leonardo Vinicius Monteiro de Assis, Lisbeth Harder ... Henrik Oster
    High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.
    1. Developmental Biology

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

    Sylvie Remaud, Fernando C Ortiz ... Barbara Demeneix
    Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
    1. Developmental Biology

    Visually induced changes in cytokine production in the chick choroid

    Jody A Summers, Elizabeth Martinez
    IL-6 gene and protein expression are rapidly and transiently upregulated in the choroid in response to myopic defocus, as a result of prior form deprivation or treatment with +15 D lenses in a nitric oxide-dependent manner.

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