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    1. Microbiology and Infectious Disease

    Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria

    Sromona D Mukherjee, Carlos A Batagello ... Aaron W Miller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola, Calvin J Kersbergen ... Dwight E Bergles
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Cell Biology

    Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

    Aidan M Fenix, Abigail C Neininger ... Dylan T Burnette
    Sarcomeres in heart muscle cells come from stress fiber-like structures that are mechanistically distinct from stress fibers in non-muscle cells.
    1. Neuroscience

    Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    Viktor János Oláh, Jing Wu ... Matthew JM Rowan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular tuning of sea anemone stinging

    Lily S He, Yujia Qi ... Nicholas W Bellono
    Sea anemones use adapted ion channels to control stinging behavior.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

    Alessandro Bonfini, Adam J Dobson ... Nicolas Buchon
    The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
    1. Neuroscience

    Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

    Stefan Hirschberg, Yong Li ... Anthony E Pickering
    The locus coeruleus is organised into functional modules with subsets of noradrenergic neurones independently projecting to the spinal cord and prefrontal cortex to exert discrete, antithetical modulatory actions on a range of pain-related behaviours.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana C Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Cadherins regulate nuclear topography and function of developing ocular motor circuitry

    Athene Knüfer, Giovanni Diana ... Sarah Guthrie
    Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.