7,313 results found
    1. Cell Biology
    2. Developmental Biology

    Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

    Mariko Yokouchi et al.
    The three dimensional structure of epidermal cells in the stratum granulosum provides the basis for the homeostasis of the tight junction barrier during cell turnover in the skin.
    1. Cell Biology
    2. Developmental Biology

    Tight Junction Protein 1a regulates pigment cell organisation during zebrafish colour patterning

    Andrey Fadeev et al.
    The changes in shape of iridophores that underlie adult colour pattern formation in zebrafish depend on the levels of Tight Junction Protein 1a in these cells.
    1. Human Biology and Medicine
    2. Neuroscience

    Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

    Raphael M Bendriem et al.
    That early cortical neural progenitor divisions strictly require OCLN isoform expression is a paradigm shift in the functional consideration of this protein best known for promoting between-cell barrier functions.
    1. Cancer Biology
    2. Cell Biology

    AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

    Nicolas Aznar et al.
    An effector of AMPK is essential for the kinase and its pharmacological activators, including Metformin, to strengthen cell-cell junctions and preserve epithelial cell polarity and barrier functions in the face of energetic stress, as well as to suppress oncogenesis.
    1. Neuroscience

    A causal role for right temporo-parietal junction in signaling moral conflict

    Ignacio Obeso et al.
    Disrupting the right temporo-parietal junction did not change the general motivation to give or adapt behavior to social reputation cues, but specifically reduced the impact of moral-material conflict.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Claudin-2-dependent paracellular channels are dynamically gated

    Christopher R Weber et al.
    Paracellular, trans-tight junction channels, which communicate between two extracellular compartments without crossing the plasma membrane, are a new class of ion channel with unitary behaviors similar to traditional transmembrane channels.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

    Anna M Puszynska, Erin K O'Shea
    The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.
    1. Neuroscience

    Light-dependent pathways for dopaminergic amacrine cell development and function

    Teona Munteanu et al.
    Rods, not ipRGCs, are the major retinal photoreceptor impacting development of dopaminergic signaling in the retina.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Neuroscience

    Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

    Jessica E Messier et al.
    A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.

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