eLife authors answer questions about their life and work.

To celebrate five years of eLife we catch up with some of our first authors and reflect on the current state of scientific publishing and peer review.

M2 cortex-dorsolateral striatum circuit is functionally altered in Huntington's disease and, by boosting its activity, we reverse symptoms at behavioral, physiological, and morphological level in symptomatic mice.

Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.

A critical second step in DNA tethering by cohesin occurs after its stable binding to DNA, and this second step is modulated by the Smc3 ATPase active site in Saccharomyces cerevisiae.

Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.

Disrupting the activity of the medial lateral face patch (ML) using fMRI-targeted microinjections of muscimol leads to anatomically and categorically specific impairments in a naturalistic face detection task.

In addition to causing DNA damage, R-loops cause genomic instability by interfering with DNA repair.

Building on previous work (Muir et al., 2014), we validate the utility of a screen for new protein kinase substrates and define the underlying molecular basis of a new mechanism for responding to hypertonic conditions.