Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
Vincent Fontanier, Matthieu Sarazin ... Emmanuel Procyk
Single unit recordings in monkeys and biophysical modelling demonstrate that local inhibitory-controlled metastable neural states specify the temporal organization of cognitive functions in frontal areas.
Dmitry Kobak, Jose L Pardo-Vazquez ... Alfonso Renart
Representation of sound lateralisation and intensity by neural population in the rat auditory cortex strongly depends on the brain state suggesting that the neural tuning to lateralisation is not hard-wired.
Nicolás Mongiardino Koch, Jeffrey R Thompson ... Greg W Rouse
Phylogenomics of sea urchins clarifies their origins and diversification history, reveals surprising discrepancies with their rich fossil record, and serves as basis to explore the sensitivity of time calibration analysis.
Laura Lleras Forero, Rachna Narayanan ... Stefan Schulte-Merker
In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
Philippa Anne Johnson, Tessel Blom ... Hinze Hogendoorn
To accurately represent object position in real time, the human visual system predictively encodes the location of moving objects, compensating for the time required for transmission and processing of information.
A brain–computer interface for real-time identification of transient neural activity patterns enables causal inference of the role of these patterns in cognition through closed-loop manipulation.
Machine learning and experimental tests of receiver bias identify signal components critical to correct species classification in guenons, linking face pattern diversity to selection for species discrimination.
Christopher T Boughter, Martin Meier-Schellersheim
A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
