1,216 results found
    1. Neuroscience

    Nanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse

    Itaru Arai, Peter Jonas
    Ca2+ channels and release sensors at a fast central synapse are tightly coupled, which minimizes the effect of extracellular Ca2+ concentration on the timing of transmitter release.
  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: SARS-CoV-2 (COVID-19) by the numbers

    Yinon M Bar-On et al.
    Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
    1. Evolutionary Biology
    Baboon illustration

    The Natural History of Model Organisms: Insights into the evolution of social systems and species from baboon studies

    Julia Fischer et al.
    Wild baboons are an excellent model to study complex evolutionary processes such as speciation and hybridization, as well as the links between sociality, longevity and reproductive success.
    1. Evolutionary Biology
    Mouse illustration

    The Natural History of Model Organisms: Insights into mammalian biology from the wild house mouse Mus musculus

    Megan Phifer-Rixey, Michael W Nachman
    Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    Distinct roles for innexin gap junctions and hemichannels in mechanosensation

    Denise S Walker, William R Schafer
    The innexin protein UNC-7, a homologue of vertebrate pannexins, plays a specific, gap junction-independent role in C. elegans mechanosensation.
    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide et al.
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Neuroscience

    Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

    Maria Ryazantseva et al.
    Glutamatergic projections from basolateral to central amygdala, implicated in neuropsychiatric disorders, develop rapidly during early postnatal period and their development is modulated via endogenously active kainate receptors.

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