LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.

The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.

Using both electron cryo-tomography and helical reconstruction, the first structure of the entire archaellum machinery with an assembled filament has been determined, providing the structural basis for our understanding of archaeal motility.

ADP-ribosylation factor-like GTPase 15, an atypical small GTPase, binds to cystathionine-β-synthase-pair domain divalent metal cation transport mediator (CNNM) membrane proteins to inhibit divalent cation efflux by CNNM proteins and influx by transient receptor potential ion channel subfamily M member 7.

A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.

Self-reactive CD4⁺ thymocytes have a broad impact on the composition of medullary thymic epithelial cell (mTEC) subsets by acting upstream of Aire⁺ mTECs, which conditions the induction of T-cell tolerance.

EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.

Gasdermin D-mediated neutrophil pyroptosis plays an important role in driving inflammation in psoriasis, which unravels new pathogenesis of psoriasis and provides new insights into psoriasis treatment by targeting neutrophil pyroptosis.

RiboD-PETRI, a cost-effective, equipment-free plate-based scRNA-seq technique that integrates a unique bacterial rRNA depletion protocol, significantly enhancing mRNA detection rate and revealing within-population heterogeneity, offering valuable insights for research applications.

Molecular atlas of Human leg muscles molecular atlas reveals muscle-specific signatures that discriminate between muscle groups.