16,202 results found
    1. Epidemiology and Global Health

    Time-to-event modeling of hypertension reveals the nonexistence of true controls

    Daniel Shriner, Amy R Bentley ... Charles N Rotimi
    Despite health disparities among groups, the lifetime risk of hypertension approaches 100% for African Americans, European Americans, and Mexican Americans.
    1. Developmental Biology

    The Drosophila Individual Activity Monitoring and Detection System (DIAMonDS)

    Ki-Hyeon Seong, Taishi Matsumura ... Siu Kang
    The DIAMonDS can automatically and sequentially identify time points of multiple life cycle events such as pupariation, eclosion, and death in individual flies at high temporal resolution and large scale.
    1. Developmental Biology

    Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins

    Maaike Welling, Manuel Alexander Mohr ... Periklis Pantazis
    Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
    1. Neuroscience

    Hippocampal ensemble dynamics timestamp events in long-term memory

    Alon Rubin, Nitzan Geva ... Yaniv Ziv
    Temporally close events share a common timestamp regardless of the spatial context in which they occur.
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky, Janice Chen ... Kenneth A Norman
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.
    1. Neuroscience

    Representation of time interval entrained by periodic stimuli in the visual thalamus of pigeons

    Yan Yang, Qian Wang ... Qian Xiao
    The experience-dependent representation of time interval in the seconds-to-minutes range occurs as early as at the thalamic level in the brain.
    1. Neuroscience

    CA1 cell activity sequences emerge after reorganization of network correlation structure during associative learning

    Mehrab N Modi, Ashesh K Dhawale, Upinder S Bhalla
    As mice learn to associate events separated in time, neurons within the CA1 region of the hippocampus progressively reorganize their firing patterns, leading to a relay of cellular activity that bridges the two events.
    1. Evolutionary Biology

    Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

    Fabien Duveau, Andrea Hodgins-Davis ... Patricia J Wittkopp
    The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.
    1. Computational and Systems Biology
    2. Neuroscience

    A quantitative model of conserved macroscopic dynamics predicts future motor commands

    Connor Brennan, Alexander Proekt
    Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism

    Guillaume Witz, Erik van Nimwegen, Thomas Julou
    Single-cell measurements combined with a new statistical framework for discriminating between models of cell cycle regulation show that chromosome initiation controls the E. coli cell cycle via two adder mechanisms.

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