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    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Neuroscience

    The rate of transient beta frequency events predicts behavior across tasks and species

    Hyeyoung Shin, Robert Law ... Stephanie R Jones
    Across species, tasks and recording modalities, the rate of transient neocortical beta frequency (15-29Hz) events strongly predicts perceptual ability, providing fundamental mechanistic insight, with implications for tracking and manipulating brain dynamics.
    1. Computational and Systems Biology

    Selecting the most appropriate time points to profile in high-throughput studies

    Michael Kleyman, Emre Sefer ... Ziv Bar-Joseph
    The Time Point Selection (or TPS) method is a general protocol for determining sampling rates for high throughout time series biological studies, that is efficient, cheap, scalable and works well for several different types of molecular data.
    1. Neuroscience

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

    Chinnakkaruppan Adaikkan, Kobi Rosenblum
    The role of CaMKII-GluA1 in the cortex in maintaining a given taste memory trace for an aversive association has been elucidated.
    1. Neuroscience

    Spatiotemporal interplay between multisensory excitation and recruited inhibition in the lamprey optic tectum

    Andreas A Kardamakis, Juan Pérez-Fernández, Sten Grillner
    Signals conveyed from two different senses from a given point in space converge onto the same neurons of the optic tectum that trigger the gaze-control-system, and at the same time inhibit other parts of the tectal motor map.
    1. Neuroscience

    Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated

    Antonio H Lara, Gamaleldin F Elsayed ... Mark M Churchland
    Voluntary movements are preceded by a temporally flexible preparatory neural process that is present regardless of whether movement is initiated rapidly or thoughtfully.
    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic, Amanda Capes-Davis ... Anita E Bandrowski
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.
    1. Neuroscience

    Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty

    Alexandra Stolyarova, Alicia Izquierdo
    Rat orbitofrontal cortex is required to accurately represent outcome distributions, whereas basolateral amygdala is necessary for the facilitation of learning in response to surprising events.
    1. Neuroscience

    Synaptic input sequence discrimination on behavioral timescales mediated by reaction-diffusion chemistry in dendrites

    Upinder Singh Bhalla
    The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.