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    1. Physics of Living Systems

    Active morphogenesis of patterned epithelial shells

    Diana Khoromskaia, Guillaume Salbreux
    An epithelium modelled as an active, nematic surface can display flattening, budding, and tubulation morphogenetic events, which are observed during development in biological organisms.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development

    Irina Matos, Amma Asare ... Elaine Fuchs
    Progenitors establish a single-cell length WNT morphogen gradient to transmit signals directionally and differentially to neighbors.
    1. Cell Biology
    2. Developmental Biology

    Uncoupling apical constriction from tissue invagination

    SeYeon Chung, Sangjoon Kim, Deborah J Andrew
    Spatially coordinated apical constriction occurs during Drosophila salivary gland invagination, but the salivary gland can form fully internalized and elongated tubes even when this process is completely blocked.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A sex-specific evolutionary interaction between ADCY9 and CETP

    Isabel Gamache, Marc-André Legault ... Julie Hussin
    Genomics-based evidence support population- and sex-specific selection of an epistatic interaction between genetic variants in ADCY9 and CETP, genes of pharmacogenetic importance in cardiovascular diseases.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Information content differentiates enhancers from silencers in mouse photoreceptors

    Ryan Z Friedman, David M Granas ... Michael A White
    Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch, Susana Temiño, Miguel Torres
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova, Venera Weinhardt ... Joachim Wittbrodt
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.
    1. Cell Biology
    2. Computational and Systems Biology

    TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

    Raphaël Etournay, Matthias Merkel ... Frank Jülicher
    A computational framework called TissueMiner, complete with tutorials, will allow a wide range of users to perform quantitative multiscale analysis of tissue morphogenesis.
    1. Developmental Biology

    Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

    Lijuan Du, Alex Sohr ... Sougata Roy
    FGF morphogen gradient self-generates a recipient tissue-specific contour by feedback-regulating its cytoneme-mediated dispersion.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

    Wai Hoe Ng, Elizabeth K Johnston ... Xi Ren
    An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.