5,220 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone, Kirsty Hey ... Julian RE Davis
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

    Howard Choi, Deborah Simpson ... Chavaunne T Thorpe
    Metabolic labelling reveals complex proteome dynamics in tendon, with faster turnover of proteins in the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix.
    1. Cell Biology
    2. Genetics and Genomics

    Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity

    Jisun So, Olivia Strobel ... Hyun Cheol Roh
    Significant technical improvement in single-nucleus RNA-seq reveals distinct adipocyte subpopulations that respond differently to obesity, including those undergoing adaptive healthy expansion and others displaying severe dysfunction.
    1. Evolutionary Biology

    New soft tissue data of pterosaur tail vane reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins

    Natalia Jagielska, Thomas G Kaye ... Michael Pittman
    Laser-stimulated fluorescence (LSF) imaging of early pterosaurs uncovers new soft tissue data of tail vane that reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins.
    1. Developmental Biology

    Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

    Kenji Kamimoto, Kota Kaneko ... Tohru Itoh
    Clonal tracing in vivo and quantitative modeling in silico reveal a unique mode of tissue growth and structural remodeling of the biliary system, providing an insight into the cellular basis for robust liver regeneration.
    1. Developmental Biology

    Visceral organ morphogenesis via calcium-patterned muscle constrictions

    Noah P Mitchell, Dillon J Cislo ... Sebastian J Streichan
    Whole-organ live imaging and computational analysis reveal a calcium-mediated mechanical program linking gene expression to organ shape.
    1. Developmental Biology
    2. Neuroscience

    A dynamic and expandable digital 3D-atlas maker for monitoring the temporal changes in tissue growth during hindbrain morphogenesis

    Matthias Blanc, Giovanni Dalmasso ... Cristina Pujades
    The digital 3D-atlas maker will help ascribing neuronal birthdate and neuronal differentiation times upon gene disruption in zebrafish avatars for human diseases, and will allow the integration of the information generated in other laboratories.
    1. Cell Biology
    2. Computational and Systems Biology

    TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

    Raphaël Etournay, Matthias Merkel ... Frank Jülicher
    A computational framework called TissueMiner, complete with tutorials, will allow a wide range of users to perform quantitative multiscale analysis of tissue morphogenesis.
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay, Marko Popović ... Suzanne Eaton
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Physics of Living Systems

    Active morphogenesis of patterned epithelial shells

    Diana Khoromskaia, Guillaume Salbreux
    An epithelium modelled as an active, nematic surface can display flattening, budding, and tubulation morphogenetic events, which are observed during development in biological organisms.

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