1,040 results found
    1. Neuroscience

    Myomatrix arrays for high-definition muscle recording

    Bryce Chung, Muneeb Zia ... Samuel J Sober
    A novel technology for recording muscle activity provides unprecedented access to the electrical signals that control the body across muscles, species, and behaviors.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

    Susanna Lemmelä, Eleanor M Wigmore ... Athena Matakidou
    Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

    Simon Weinberger, Matthew P Topping ... Ariane Ramaekers
    The coding sequences of a very highly conserved family of neurogenic transcription factors from different species have evolved to generate proteins that have different life times causing them to display quantitatively different neural induction potentials.
    1. Developmental Biology
    2. Genetics and Genomics

    Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

    Juliet R Girard, Lauren M Goins ... Utpal Banerjee
    A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription

    Gonçalo Fernandes, Huy Tran ... Nathalie Dostatni
    The hunchback transcription features are compatible with an equilibrium model with a short decay length Bicoid activity gradient as the sole source of positional information, while Zelda and Hunchback speed-up the process by different means.
    1. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller, Trevor T-J Chong ... Clive R Rosenthal
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
    1. Plant Biology

    The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP

    Zigmunds Orlovskis, Archana Singh ... Saskia A Hogenhout
    Phytoplasma effector SAP54 hijacks previously unknown MADS-box protein roles in plant-insect interactions by modulating plant biotic stress responses to male leafhoppers and facilitating female attraction and reproduction on male-exposed leaves.

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