3,289 results found
    1. Neuroscience

    Extracellular space preservation aids the connectomic analysis of neural circuits

    Marta Pallotto et al.
    Automated segmentation of neurons and identification of synapses in electron micrographs is significantly improved by using simple modifications to chemical fixation protocols that preserve extracellular space in the brain.
    1. Neuroscience

    Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

    Hiromi Tamada et al.
    Cryo preservation of brain tissue reveals dendritic spines with thinner necks compared to those prepared with chemical fixation.
    1. Neuroscience

    Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

    Natalya Korogod et al.
    Snap-freezing of brain tissue reveals its true structure-showing that cells are less squashed together, and the connections between neurons are less enclosed than previously thought.
    1. Cell Biology

    Automated cell-type classification in intact tissues by single-cell molecular profiling

    Monica Nagendran et al.
    The ability to rapidly stain for any combination of genes in intact tissue with automated quantification of transcripts in individual cells and spatial re-mapping affords new insights into lung biology, and will greatly accelerate progress in scientific and medical research.
    1. Neuroscience

    Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

    Luis Alarcon-Martinez et al.
    Pericytes surrounding capillaries in the retina contain α-smooth muscle actin, demonstrating that pericytes have the necessary molecular machinery to change capillary diameter during neurovascular coupling.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke et al.
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Evolutionary Biology

    Spatio-temporal control of mutualism in legumes helps spread symbiotic nitrogen fixation

    Benoit Daubech et al.
    Experiments and mathematical modelling show that rare nitrogen fixing symbionts invade a population dominated by non-fixing bacteria across plant generations, above a threshold of a combination of ecological factors.
    1. Biochemistry and Chemical Biology

    Meta-Research: Task specialization across research careers

    Nicolas Robinson-Garcia et al.
    An analysis of author contribution statements in a large number of published papers reveals biases in the career trajectories of scientists.
    1. Biochemistry and Chemical Biology

    Point of View: How open science helps researchers succeed

    Erin C McKiernan et al.
    Open research practices bring significant benefits to researchers.

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