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    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai, Aurelie Bertin ... Patricia Bassereau
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou, Kuhulika Bhalla ... Bruce Stillman
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Cell Biology
    2. Physics of Living Systems

    De novo identification of universal cell mechanics gene signatures

    Marta Urbanska, Yan Ge ... Jochen Guck
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

    Kerstin Klinkert, Nicolas Levernier ... Pierre Gönczy
    Experiments reveal mechanisms through which Caenorhabditis elegans zygotes depleted of Aurora A or lacking centrosomes spontaneously establish two posterior PAR-2 domains, one at each pole, in a curvature-dependent manner.
    1. Neuroscience

    The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

    Lydia Gruber, Rafael Cantera ... Jürgen Rybak
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Suppression of transcytosis regulates zebrafish blood-brain barrier function

    Natasha M O'Brown, Sean G Megason, Chenghua Gu
    The zebrafish has been established as a genetic and molecular model for the blood-brain barrier.
    1. Ecology
    2. Microbiology and Infectious Disease

    Gastrointestinal helminths increase Bordetella bronchiseptica shedding and host variation in supershedding

    Nhat TD Nguyen, Ashutosh K Pathak, Isabella M Cattadori
    Helminth infected hosts are an important cause of variation in the level, frequency and duration of Bordetella bronchiseptica shedding and dynamics of infection.
    1. Neuroscience

    A compositional neural code in high-level visual cortex can explain jumbled word reading

    Aakash Agrawal, KVS Hari, SP Arun
    Viewing a jumbled word activates an efficient visual representation in high-level visual cortex that is matched to stored words in the word form area.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

    David B Doroquez, Cristina Berciu ... Daniela Nicastro
    The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.