8,467 results found
    1. Developmental Biology
    2. Physics of Living Systems

    Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye

    Kevin D Gallagher, Madhav Mani, Richard W Carthew
    Formation of a triangular lattice of photoreceptor clusters in the compound eye is driven by highly regulated cell flows in the eye epithelium, through a mechanochemical mechanism.
    1. Developmental Biology
    2. Physics of Living Systems

    Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

    Amelia J Thompson, Eva K Pillai ... Kristian Franze
    During embryonic development, tissue stiffness, which provides an important signal to motile cells, changes locally within tens of minutes in a well-controlled manner.
    1. Developmental Biology
    2. Physics of Living Systems

    Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing

    Romina Piscitello-Gómez, Franz S Gruber ... Suzanne Eaton
    Quantitative analysis of cell dynamics over a range of timescales reveals that core PCP is not required to organize large-scale tissue flows but does affect short timescale mechanics.
    1. Physics of Living Systems

    Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing

    Alessandro Sanzeni, Samata Katta ... Massimo Vergassola
    Nonlinear elasticity of skin tissues and somatosensory neural responses are combined to predict and test C. elegans processing of touch stimuli and modifications due to changes in the body mechanics.
    1. Physics of Living Systems
    2. Developmental Biology

    Unified quantitative characterization of epithelial tissue development

    Boris Guirao, Stéphane U Rigaud ... Yohanns Bellaïche
    A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay, Marko Popović ... Suzanne Eaton
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Physics of Living Systems

    Generating active T1 transitions through mechanochemical feedback

    Rastko Sknepnek, Ilyas Djafer-Cherif ... Silke Henkes
    Directed mechanical stresses can trigger active T1 events that lead to tissue elongation perpendicular to the main direction of tissue stress.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf, Alasdair Ivens, Philip J Spence
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.
    1. Developmental Biology

    A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

    Nicholas S Kalson, Yinhui Lu ... Karl E Kadler
    Tendon fibroblast cells lay down a collagen matrix template during embryogenesis, and the expansion of this matrix drives post-natal tissue growth.
    1. Stem Cells and Regenerative Medicine

    Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling

    Michael A Gaviño, Danielle Wenemoser ... Peter W Reddien
    Flatworm regeneration of lost tissue relies on a mechanism distinct from that used for routine tissue turnover.

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