8,552 results found
    1. Neuroscience

    Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

    Michael J Goard, Gerald N Pho ... Mriganka Sur
    Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
    1. Ecology
    2. Evolutionary Biology

    Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila

    Heather E Machado, Alan O Bergland ... Dmitri A Petrov
    Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

    Laura M Doherty, Caitlin E Mills ... Peter K Sorger
    The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.
    1. Cancer Biology
    2. Computational and Systems Biology

    Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

    Simon P Hood, Georgina Cosma ... A Graham Pockley
    Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan, Thomas Meyer ... Marlene Bartos
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock, Danitra Parker ... Kasturi Mitra
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Neuroscience

    Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning

    Hélène Vitet, Julie Bruyère ... Frédéric Saudou
    Studies in mice and neurons reveal how modulation of the axonal transport of synaptic vesicles via huntingtin phosphorylation influences the number of vesicles accumulating at the synapse, subsequent glutamate release, and behavior in mice.
    1. Neuroscience

    Damage to the right insula disrupts the perception of affective touch

    Louise P Kirsch, Sahba Besharati ... Aikaterini Fotopoulou
    Lesion analyses in right hemisphere stroke patients reveal the crucial role of the right anterior and posterior insula in the perception of affective touch.
    1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult
    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.
    1. Neuroscience

    Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates

    Ying Huang, Artur Matysiak ... Michael Brosch
    The auditory cortex temporarily stores task-relevant information by persistently changed neuronal activity of single neurons and of neuronal populations.

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