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    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

    Alberto Brandariz-Nuñez et al.
    Internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a cell nucleus, causing infection.
    1. Immunology and Inflammation

    The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets

    Takuya Koike et al.
    Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk et al.
    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker et al.
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant et al.
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Neuroscience

    Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics

    Mladen Barbic
    Several new magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics are proposed that may explain some of the mysteries that challenge current understanding of the magnetogenetics experiments.
    1. Genetics and Genomics
    2. Neuroscience

    Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive

    Yoonhee Ki, Chunghun Lim
    Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

    Lauren N Booth et al.
    Nematode hermaphroditism has co-evolved with a self-sperm sensing mechanism that protects hermaphrodites from the detrimental effects of mating with males.
    1. Neuroscience

    Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience

    Fabian Grabenhorst et al.
    Neurons in prefrontal cortex track the variance of experienced rewards to guide economic decisions.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Absolute quantification of cohesin, CTCF and their regulators in human cells

    Johann Holzmann et al.
    Absolute quantification of cohesin, CTCF, NIPBL, WAPL and sororin in HeLa cells implies that some genomic cohesin and CTCF enrichment sites are unoccupied at any one time.