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3,548 results found
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge et al.
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta et al.
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Chromosomes and Gene Expression

    Translation affects mRNA stability in a codon-dependent manner in human cells

    Qiushuang Wu et al.
    Genomic-profiles and reporters reveal that the three-nucleotide ‘words’ read by the ribosome, codons, have a strong effect on mRNA stability, impacting the homeostatic mRNA and protein levels in human cells.
    1. Cell Biology

    Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

    Jonathan O Nelson et al.
    Excess expression of the Gadd45 mRNA accounts for lethality when nonsense-mediated decay is lost in Drosophila and mammalian cells, revealing that this pathway is a critical gene regulatory mechanism.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan et al.
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Cell Biology
    2. Genetics and Genomics

    Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest

    Noa Aharon-Hefetz et al.
    Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

    Chen Bao et al.
    By sterically hindering tRNA binding and inhibiting translation elongation, mRNA stem-loops can modulate gene expression.
    1. Chromosomes and Gene Expression

    Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

    Jun Yao et al.
    Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
    1. Chromosomes and Gene Expression

    A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

    William R Brothers et al.
    Crosslink immunopreciptiation (iCLIP) studies reveal important mechanistic insights into how MARF1 post-transcriptionally regulates targeted mRNAs and uncover a novel mode by which EDC4 regulates mRNA metabolism.

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