65 results found
    1. Developmental Biology

    Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

    Megan L Norris et al.
    Elucidation of direct and indirect roles of GPCR signaling during gastrulation.
    1. Neuroscience

    Early alterations of social brain networks in young children with autism

    Holger Franz Sperdin et al.
    Toddlers with autism spectrum disorders have alterations in gaze patterns together with frequency specific network atypicalities between key brain areas of the social brain when freely exploring naturalistic and ecologically valid dynamic social stimuli.
    1. Neuroscience

    Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties

    Michael V Lombardo et al.
    Functional hypoconnectivity between ‘social brain’ default mode circuitry and visual association cortex underpins a subtype of autistic toddlers with a strong preference to attend to the non-social visual world.
    1. Epidemiology and Global Health
    2. Medicine

    Mathematical modeling of the West Africa Ebola epidemic

    Jean-Paul Chretien et al.
    A review of mathematical models applied to the West Africa Ebola epidemic suggests ways to improve the use of mathematical modeling in responding to public health emergencies.
  1. Scientist and Parent: Learning lessons from a toddler

    Madhumala K Sadanandappa
    Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter.
    1. Neuroscience

    Ten simple rules for the computational modeling of behavioral data

    Robert C Wilson, Anne GE Collins
    Computational modeling of cognitive and neuroscience data is an insightful and powerful tool, but has many potential pitfalls that can be avoided by following simple guidelines.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner et al.
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    NetPyNE, a tool for data-driven multiscale modeling of brain circuits

    Salvador Dura-Bernal et al.
    The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.
    1. Neuroscience

    Spike frequency adaptation supports network computations on temporally dispersed information

    Darjan Salaj et al.
    Spike frequency adaptation provides spiking neural networks with long short-term memory.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson et al.
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.

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