30 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer et al.
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Developmental Biology

    Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

    Edward Kim et al.
    Nf1 is required during early, but not late, cerebellar development to facilitate neuronal lamination, providing a potential therapeutic prevention strategy for NF1-associated developmental abnormalities.
    1. Developmental Biology
    2. Human Biology and Medicine

    The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

    Christian SM Helker et al.
    Elabela-Apelin receptor signaling is a novel pathway that regulates angioblast migration, instead of the proposed migration regulation through Vascular endothelial growth factor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Consistent global structures of complex RNA states through multidimensional chemical mapping

    Clarence Yu Cheng et al.
    A multidimensional chemical mapping strategy enables confident determination of the structures of non-coding RNAs at 1-nm resolution, including previously intractable riboswitch and human regulon states.
    1. Neuroscience

    AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae

    Mohini Sengupta, Vatsala Thirumalai
    In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.
    1. Epidemiology and Global Health

    The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

    Katia Koelle, David A Rasmussen
    Deleterious mutations slow down flu's antigenic evolution, make it more punctuated in nature, and reduce the virus's genetic diversity.
    1. Neuroscience

    Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus

    Diek W Wheeler et al.
    Hippocampome.org is an online resource that provides free human- and machine-readable access to the comprehensive property-based classification of hippocampal neurons from 14,000 pieces of published experimental evidence.
    1. Cell Biology
    2. Computational and Systems Biology

    Evaluation of predictions of the stochastic model of organelle production based on exact distributions

    C Jeremy Craven
    A reanalysis of the stochastic model of organelle production (Mukherji and O'Shea, 2014) suggests that this model requires significant further discussion.
    1. Epidemiology and Global Health

    Childhood injury after a parental cancer diagnosis

    Ruoqing Chen et al.
    Children with a parent of cancer have a higher rate of hospital contact for injury, especially immediately after the cancer diagnosis.
    1. Epidemiology and Global Health

    Mathematical modeling of the West Africa Ebola epidemic

    Jean-Paul Chretien et al.
    A review of mathematical models applied to the West Africa Ebola epidemic suggests ways to improve the use of mathematical modeling in responding to public health emergencies.

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