561 results found
    1. Neuroscience

    Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination

    Edward Stanek IV et al.
    Retrograde tracing of the neural circuits that control movement of the jaw and tongue reveals how shared premotor neurons help to ensure coordinated muscle activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions

    Li He et al.
    The placement of single methyl groups at certain positions in the sequence of small model transmembrane proteins consisting solely of leucines and isoleucines can modulate highly specific, productive interactions with the transmembrane domain of the erythropoietin receptor.
    1. Medicine

    Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

    AJ Venkatakrishnan et al.
    SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
    1. Neuroscience

    Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis

    Sergey D Stavisky et al.
    Neurons in human dorsal motor cortex, an area involved in controlling arm and hand movements, are also active – and show similar ensemble dynamics – during speaking.
    1. Computational and Systems Biology
    2. Neuroscience

    A connectome and analysis of the adult Drosophila central brain

    Louis K Scheffer et al.
    New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet et al.
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.
    1. Neuroscience

    Spike frequency adaptation supports network computations on temporally dispersed information

    Darjan Salaj et al.
    Spike frequency adaptation provides spiking neural networks with long short-term memory.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

    Lakshya Chauhan et al.
    Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden et al.
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.

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