Other than its function in mechanotransduction, TMC1 is indispensable for action potential firing of auditory hair cells by mediating a leak conductance that alters tonotopically along the cochlea coil.
Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
Ultra-high field neuroimaging dissects the ventral medial geniculate body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that vMGB top-down modulation is relevant for speech recognition.
fMRI data from macaques suggest that sounds with similar temporal characteristics activate neighbouring regions of auditory cortex, giving rise to a topographic map broadly analogous to that for sound frequencies.
The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.