563 results found
    1. Cell Biology

    Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

    Kelsey R Baron, Samantha Oviedo ... R Luke Wiseman
    Compounds that activate integrated stress response kinases inhibit mitochondrial fragmentation induced by chemical or genetic insults, indicating that targeting this pathway offers opportunities to mitigate mitochondrial fragmentation in diverse diseases.
    1. Genetics and Genomics

    Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies

    Jorge Blanco Mendana, Margaret Donovan ... Daryl M Gohl
    A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.
    1. Neuroscience

    Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner

    Xin Zhao, Yurim Chae ... Katherine Tschida
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology
    2. Evolutionary Biology

    Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes

    Hope M Healey, Hayden B Penn ... William A Cresko
    The production of a single-cell atlas for developing syngnathid fish permits study of their unique traits.
    1. Evolutionary Biology

    Large inversions in Lake Malawi cichlids are associated with habitat preference, lineage, and sex determination

    Nikesh M Kumar, Taylor L Cooper ... Patrick T McGrath
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Neuroscience

    Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins

    Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
    Mechanosensory isolation of C. elegans nematodes independently induces homeostatic structural changes in the dendritic tree and differential response to mechanical stimulation, both these structural and behavioral outcomes are mediated by degenerins and do not affect presynaptic calcium dynamics.
    1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi ... Joachim HR Lübke
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    • Incomplete
    1. Neuroscience

    Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

    Friederike Steenken, Rainer Beutelmann ... Georg M Klump
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology
    2. Neuroscience

    Multisensory integration operates on correlated input from unimodal transient channels

    Cesare V Parise, Marc O Ernst
    Psychophysical experiments and computational modeling demonstrate the importance of transient, instead of sustained, channels for the integration of audiovisual signals.
    1. Neuroscience

    Auditory cortex anatomy reflects multilingual phonological experience

    Olga Kepinska, Josue Dalboni da Rocha ... Narly Golestani
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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