563 results found
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

    Michael J Abrams, Fayth Hui Tan ... Lea Goentoro
    Amino acid and sugar supplement induce appendage/limb regeneration in cnidarians, insects, and mammals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

    Caitlyn L McCafferty, Ophelia Papoulas ... Edward M Marcotte
    The 3D structure of the six-subunit complex and its polymeric assembly gives insights into cargo transport in cilia and how specific mutations in these genes lead to ciliopathy birth defects.
    1. Neuroscience

    Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner

    Xin Zhao, Yurim Chae ... Katherine Tschida
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

    Yul HR Kang, Anne Löffler ... Michael N Shadlen
    When making two decisions about one object, two streams of information can be acquired in parallel but must be incorporated into the two decisions serially, consistent with a central bottleneck.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A conserved filamentous assembly underlies the structure of the meiotic chromosome axis

    Alan MV West, Scott C Rosenberg ... Kevin D Corbett
    Meiotic chromosome axis 'core' proteins from fungi, plants, and mammals form a conserved filament architecture, and use a common mechanism to recruit HORMAD proteins for meiotic recombination control.
    1. Neuroscience

    Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

    Friederike Steenken, Rainer Beutelmann ... Georg M Klump
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers, Amanda P Smith ... Amber M Smith
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.
    1. Cell Biology

    Exploring the role of macromolecular crowding and TNFR1 in cell volume control

    Parijat Biswas, Priyanka Roy ... Deepak Kumar Sinha
    Cells adapt to extracellular hypertonicities using regulatory volume increase (RVI), and TNFR1-mediated NFkB activation is indispensable for RVI, but the increased cytoplasmic macromolecular crowding can inhibit TNFR1 signaling and prevent RVI at severe hypertonicities.
    1. Neuroscience

    Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations

    Alina Peter, Cem Uran ... Martin Vinck
    Colored surfaces induce strong gamma-synchronization yet sparse firing in V1 when receptive field inputs are predicted from the surrounding spatial context.

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