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    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent evolution of high virulence in isolated populations of a DNA virus

    Tom Hill, Robert L Unckless
    The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.
    1. Neuroscience

    Unifying network model links recency and central tendency biases in working memory

    Vezha Boboeva, Alberto Pezzotta ... Athena Akrami
    Seemingly disparate working memory biases, including short-term serial and contraction biases, may arise from a common mechanism via the interaction of multiple networks, each operating over a distinct timescale.
    1. Cancer Biology
    2. Cell Biology

    Augmin prevents merotelic attachments by promoting proper arrangement of bridging and kinetochore fibers

    Valentina Štimac, Isabella Koprivec ... Iva M Tolić
    STED microscopy of human mitotic spindles reveals how augmin-nucleated microtubules protect the cell from erroneous kinetochore-microtubule attachments and ensure a highly organized architecture of the spindle required for mitotic fidelity.
    1. Evolutionary Biology

    Heterozygote advantage can explain the extraordinary diversity of immune genes

    Mattias Siljestam, Claus Rueffler
    An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
    1. Neuroscience
    2. Physics of Living Systems

    Unsupervised Bayesian Ising Approximation for decoding neural activity and other biological dictionaries

    Damián G Hernández, Samuel J Sober, Ilya Nemenman
    The proposed method deciphers which low-level patterns (such as spikes) control high-level features (behavior) in relative small biological datasets, taking into account the statistical dependencies between such patterns.
    1. Cell Biology

    Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

    Fabian Link, Alyssa Borges ... Markus Engstler
    The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
    1. Cell Biology
    2. Developmental Biology

    Radially patterned cell behaviours during tube budding from an epithelium

    Yara E Sanchez-Corrales, Guy B Blanchard, Katja Röper
    Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.
    1. Cell Biology
    2. Physics of Living Systems

    The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

    Akanksha Thawani, Michael J Rale ... Sabine Petry
    Four αβ-tubulin dimers associate laterally on γ-TuRC to define the rate-limiting transition state for microtubule nucleation.
    1. Neuroscience

    Controlling motor neurons of every muscle for fly proboscis reaching

    Claire E McKellar, Igor Siwanowicz ... Julie H Simpson
    A new collection of fly strains comprehensively targets the motor neurons of the proboscis, allowing separate control of every muscle to determine how this appendage achieves flexible, directed reaching.
    1. Immunology and Inflammation
    2. Medicine

    Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

    Alex Moshensky, Cameron S Brand ... Laura E Crotty Alexander
    Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.