429 results found
    1. Chromosomes and Gene Expression

    Cohesin architecture and clustering in vivo

    Siheng Xiang, Douglas Koshland
    Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli et al.
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.
    1. Chromosomes and Gene Expression

    Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

    Gang Wu et al.
    RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde et al.
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Residue-by-residue analysis of cotranslational membrane protein integration in vivo

    Felix Nicolaus et al.
    The cotranslational membrane integration of three multispanning Escherichia coli inner membrane proteins is followed using force profile analysis, uncovering unexpected complexities in the membrane integration process.
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig et al.
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Developmental Biology
    2. Genetics and Genomics

    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J Geusz et al.
    Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
    1. Structural Biology and Molecular Biophysics

    Structural basis for transcription complex disruption by the Mfd translocase

    Jin Young Kang et al.
    Seven distinct cryo-electron microscopy structures delineate the elaborate mechanism for how E. coli Mfd, a transcription repair coupling factor, disassembles the RNA polymerase transcription elongation complex to initiate transcription-coupled repair.
    1. Computational and Systems Biology

    Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species

    Arnaud Belcour et al.
    Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.

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