12,468 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A distinct transition from cell growth to physiological homeostasis in the tendon

    Mor Grinstein et al.
    Mitotic labeling defines a change in cell division kinetics from growth to homeostasis and identifies slowly cycling cells in the adult tendon.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

    Ursula Schulze-Gahmen et al.
    AFF4 increases the combined selectivity of HIV Tat and TAR for super elongation complexes 330-fold over P-TEFb alone.
    1. Neuroscience

    MAPLE (modular automated platform for large-scale experiments), a robot for integrated organism-handling and phenotyping

    Tom Alisch et al.
    A new versatile, autonomous, robotic experimental platform (MAPLE) can increase the throughput of biological experiments by automating the growth and phenotyping of a variety of model organisms.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken et al.
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley et al.
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
    1. Cell Biology
    2. Genetics and Genomics

    Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

    Yael Riahi et al.
    mTORC1 inhibition by perinatal ER stress induces beta-cell growth arrest with subsequent development of diabetes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.
    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.
    1. Neuroscience

    Early life experience sets hard limits on motor learning as evidenced from artificial arm use

    Roni O Maimon-Mor et al.
    Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

    Ursula Schulze-Gahmen et al.
    Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex
    1. Epidemiology and Global Health

    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

    Jaspreet Toor et al.
    Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.

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