Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.

Being born late in the active season is associated with a fast life history in a hibernating species, the garden dormouse (Eliomys quercinus).

Dormice born late in the year start to prepare for winter sooner than mice born earlier in the year.

Novel heart rate strategies that minimize energy expenditure during the day are necessary to cope with high energy nocturnal lifestyles of tent-making bats.

In the torpid hibernator, when transcription is inhibited, enhanced stability and polyadenylation explain increased abundance of crucial transcripts required for intense non-shivering thermogenesis during arousal.

The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.

The biomedical research enterprise in the US has become unsustainable and urgent action is needed to address a variety of problems.