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    1. Stem Cells and Regenerative Medicine

    Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

    Francisca Benavente, Katja M Piltti ... Aileen Anderson
    Complement C1q directly drives the behavior of human neural stem cells via a classical receptor signaling mechanism modulating their capacity for functional integration in vivo.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    J Stephan Wichers, Gerry Tonkin-Hill ... Anna Bachmann
    Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode, Reed L Ressler ... Stephen Maren
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
    1. Neuroscience

    Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons

    Hiroki Ito, Anna C Sales ... Anthony E Pickering
    Ponto-spinal CRH neurons in Barrington’s nucleus are a core component of an inferential circuit that regulates autonomous micturition and generates voids when the bladder is full.
    1. Neuroscience

    Molecular characteristics and laminar distribution of prefrontal neurons projecting to the mesolimbic system

    Ákos Babiczky, Ferenc Matyas
    Molecular, laminar, and regional characterization in combination with classical and conditional tracing techniques reveal that medial prefrontal cortical neurons innervating the nucleus accumbens and the ventral tegmental area form distinct populations.
    1. Neuroscience

    The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin

    Hemin Feng, Junfeng Su ... Jufang He
    Cholecystokinin-positive neural projection from entorhinal cortex to lateral amygdala modulates the long-term potentiation of auditory-evoked potential in lateral amygdala and underlies the formation of trace fear memory.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson, Adam M Sandor ... Jordan Jacobelli
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook, Shankar Ramachandran ... Michael M Francis
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.