8 results found
    1. Stem Cells and Regenerative Medicine

    Stem cell transplantation rescued a primary open-angle glaucoma mouse model

    Siqi Xiong et al.
    Stem cell transplantation reduces intraocular pressure and preserves retinal ganglion cell function in a mouse glaucoma model, which could lead to a novel therapy for glaucoma to preserve vision.
    1. Medicine

    Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

    Guorong Li et al.
    An FDA-approved, rho-associated kinase inhibitor reverses fibrosis in the conventional outflow pathway of a mouse model of glaucoma and reverses ocular hypertension in patients with steroid glaucoma.
    1. Developmental Biology

    Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

    Benjamin R Thomson et al.
    Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal et al.
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
    1. Cell Biology
    2. Developmental Biology

    Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure

    Ian A Swinburne et al.
    The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene et al.
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
    1. Medicine

    The role of extracellular matrix phosphorylation on energy dissipation in bone

    Stacyann Bailey et al.
    Global extracellular bone matrix phosphorylation level is optimized for appropriate mechanical function and is affected by the presence and heterogeneity in phosphorylation of osteopontin.
    1. Neuroscience

    Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

    Jie Zhang et al.
    An effective and reversible mouse glaucoma model that replicates the secondary glaucoma in human patients caused by silicone oil after retina surgeries presents significant neurodegeneration, and is suitable for neuroprotectants selection.

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