15 results found
    1. Cell Biology
    2. Developmental Biology

    Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

    Jialing Qi, Annegret Rittershaus ... Christian SM Helker
    Apelin signaling-dependent endocardial protrusions promote cardiac trabeculation through Nrg/ErbB/Erk signaling in zebrafish.
    1. Cell Biology
    2. Developmental Biology

    Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

    Ryuichi Fukuda, Alla Aharonov ... Didier YR Stainier
    3D single cell imaging and genetic analyses reveal a new role of cardiac metabolism in cardiac wall morphogenesis.
    1. Developmental Biology

    Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming

    Manuel Gálvez-Santisteban, Danni Chen ... Neil C Chi
    The heart is able to sense and adaptively respond to environmental changes due to cardiac injury through flow-mediated mechanisms that regulate cardiomyocyte reprogramming and regeneration.
    1. Cell Biology
    2. Developmental Biology

    The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

    Alessandra Gentile, Anabela Bensimon-Brito ... Didier YR Stainier
    The transcription factor Snai1b maintains the myocardial wall integrity by limiting cell extrusions and regulating the intermediate filament gene desmin b.
    1. Developmental Biology

    Multiscale cardiac imaging spanning the whole heart and its internal cellular architecture in a small animal model

    Graham Rykiel, Claudia S López ... Sandra Rugonyi
    Correlative imaging of the heart at multiple spatial scales has the potential to revolutionize the way we understand deficiencies in congenital heart disease.
    1. Stem Cells and Regenerative Medicine

    Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

    Matthew Gemberling, Ravi Karra ... Kenneth D Poss
    Neuregulin1 is induced upon cardiac injury in adult zebrafish, and is sufficient to drive massive proliferative growth of the heart.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Developmental Biology

    The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

    Seyed Javad Rasouli, Mohamed El-Brolosy ... Didier Y Stainier
    Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
    1. Stem Cells and Regenerative Medicine

    Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

    John B Lees-Shepard, Sarah-Anne E Nicholas ... David J Goldhamer
    Daily palovarotene treatment reduces pathogenic expansion of fibro/adipogenic progenitors but results in long bone growth plate loss and overgrowths of synovial cartilage in juvenile mice.

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