5,309 results found
    1. Cell Biology
    2. Developmental Biology

    Ovulation in Drosophila is controlled by secretory cells of the female reproductive tract

    Jianjun Sun, Allan C Spradling
    Secretory cells in the fruit fly reproductive tract produce secretions that control ovulation through a conserved mechanism that could provide insights into ovarian cancer.
    1. Microbiology and Infectious Disease

    HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

    Tongcui Ma et al.
    CD4+ T cells from the female reproductive tract are unusually susceptible to HIV infection and are altered by HIV in ways that promote survival and systemic spread of the virus.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Polypyrimidine tract-binding proteins are essential for B cell development

    Elisa Monzón-Casanova et al.
    The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) is essential for B cell development at the pro-B cell stage where it suppresses S-phase entry and promotes progression through mitosis.
    1. Developmental Biology

    Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

    Jean-François Darrigrand et al.
    New views on the relevance of bone morphogenetic protein signalling fine tuning in the cardiac neural crest cells for the heart outflow tract septation and the formation of the great arteries.
    1. Developmental Biology

    Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

    Giulia LM Boezio et al.
    Alk5/TGF-β signaling is required in the endothelium to orchestrate zebrafish cardiac outflow tract morphogenesis, regulating smooth muscle cell and extracellular matrix organization.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Ioanna Oikonomidi et al.
    Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

    Adam Graham Grieve et al.
    The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).
    1. Computational and Systems Biology
    2. Developmental Biology

    Untwisting the Caenorhabditis elegans embryo

    Ryan Patrick Christensen et al.
    Open-source software can untwist images of live Caenorhabditis elegans embryos, allowing epidermal and neuronal cell position and morphology to be examined in previously inaccessible developmental time periods.
    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados et al.
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.
    1. Developmental Biology
    2. Neuroscience

    Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus

    Jessica E Biddinger et al.
    Leptin acts cell autonomously on brainstem neurons that express GLP-1 to suppress development of excitatory viscerosensory inputs to the hypothalamus.

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