4,351 results found
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

    Rachel Waymack et al.
    Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
    1. Developmental Biology
    2. Genetics and Genomics

    Delineating the early transcriptional specification of the mammalian trachea and esophagus

    Akela Kuwahara et al.
    Tracheal and esophageal fate specification underlies human structural anomalies, multiple cancers, and human pluripotent stem cell approaches for generating respiratory and esophageal cell types for tissue engineering.
    1. Neuroscience

    One-shot learning and behavioral eligibility traces in sequential decision making

    Marco P Lehmann et al.
    Human learning relies on short-term memories (eligibility traces) which provide a mechanism to reinforce sequences of actions from a single reward (one-shot).
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins

    Meghan Whitney Franklin et al.
    There is a strand-based evolutionary mechanism for the diversification of outer membrane proteins, which has implications for how repeat proteins are created and for how outer membrane proteins fold.
    1. Neuroscience

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

    Chinnakkaruppan Adaikkan, Kobi Rosenblum
    The role of CaMKII-GluA1 in the cortex in maintaining a given taste memory trace for an aversive association has been elucidated.
    1. Developmental Biology

    Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea

    Takefumi Kondo, Shigeo Hayashi
    The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
    1. Developmental Biology

    Developmental compartments in the larval trachea of Drosophila

    Prashanth R Rao et al.
    Cells in the tracheal systems of fruit fly larvae are organised into compartments with precisely located boundaries, which pattern the formation of branched tubular networks.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Cell Biology
    2. Developmental Biology

    A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea

    Arzu Öztürk-Çolak et al.
    Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
    1. Neuroscience

    TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions

    Zhiguo Ma, Marc R Freeman
    Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.

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