Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.

The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.

Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.

A brain descending interneuron can coordinate a switch between two antagonistic behaviors (forward and backward locomotions).

Using bioinformatic and biochemical approaches, the study has explained the discriminator base anomaly in bacterial tRNA(Gly) through identification of the key determinant of DTD specificity.

Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.

An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

New technology for manipulating genes in Drosophila facilitates gene tagging and precise modification of virtually any gene.

A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.