4,845 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein et al.
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Cell Biology
    2. Developmental Biology

    Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

    Valerie S Salazar et al.
    A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol et al.
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Developmental Biology
    2. Neuroscience

    Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

    Luis F Sullivan et al.
    The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
  1. Levelling Up: Reproducibility for Everyone

    A project supported by eLife Ambassadors and a Mozilla Mini Grant is increasing its capacity to train researchers in reproducible research practices.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell et al.
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.
    1. Cell Biology

    Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism

    Sam Li et al.
    A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.
    1. Cell Biology
    2. Developmental Biology

    zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

    Naoya Yamaguchi et al.
    The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
    1. Neuroscience

    Long-term consequences of the absence of leptin signaling in early life

    Angela M Ramos-Lobo et al.
    A mouse model that grew without functional leptin receptors until adulthood reveals that early defects in leptin signaling lead to permanent metabolic and developmental problems.
    1. Neuroscience

    Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons

    Ross S Williamson, Daniel B Polley
    Targeted recordings from subcortical projection neurons in the auditory cortex reveal two cell classes with distinct signatures of sensory processing and different patterns of local and long-range connectivity.

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