49 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

    Yulong Qiao, Qiang Sun ... Huating Wang
    YTHDC1 is an essential factor controlling satellite cell regenerative ability through multifaceted gene regulatory mechanisms in myoblast cells.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie, Mengdi Wang ... Xiaoqun Wang
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.
    1. Cell Biology

    ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

    Qi Zeng, Chen Yao ... Shuai Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

    Yingjie Sun, Changheng Li ... Youngnam N Jin
    Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.
    1. Microbiology and Infectious Disease

    Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Yajun Zhai
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Microbiology and Infectious Disease

    PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites

    Heledd Davies, Hugo Belda ... Moritz Treeck
    A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.
    1. Genetics and Genomics

    Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

    Haiko Schurz, Vivek Naranbhai ... International Tuberculosis Host Genetics Consortium
    Results from the largest tuberculosis genome-wide association study meta-analysis identified a significant association in the human leukocyte antigen class II region, rs28383206, across multiple populations.
    1. Genetics and Genomics

    Expansion of the circadian transcriptome in Brassica rapa and genome-wide diversification of paralog expression patterns

    Kathleen Greenham, Ryan C Sartor ... C Robertson McClung
    Whole genome duplication in Brassica rapa is accompanied by both expansion of the circadian transcriptome and widespread temporal reconfiguration of gene regulatory networks consistent with subfunctionalization among pairs of paralogs.

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