Indoxyl sulfate, a key uremic toxin in chronic kidney disease (CKD), induces trained immunity in monocytes via crosstalk between aryl hydrocarbon receptor (AhR)-dependent epigenetic reprogramming by enhancement of the arachidonic acid pathway and AhR-independent metabolic rewiring.

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Enriched dietary SFAs, specifically palmitic acid (PA), induce a broad and long-lived innate immune memory response which is harmful during disease exacerbated by inflammation, but beneficial for pathogen clearance.

Intranasal immunization of inactivated whole cell of some Gram-negative bacteria induces very rapid and efficient protection against bacterial pulmonary by training alveolar macrophage response, which can be harnessed to design rapid-effecting vaccine against multidrug-resistant bacteria infection.

In patients with coronary artery disease, bone marrow myeloid progenitor cells are reprogrammed towards myeloid skewing and inflammatory activation.

scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.

'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.

Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.