1,211 results found
    1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi, Arbel Harpak ... Molly Przeworski
    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.
    1. Computational and Systems Biology
    2. Ecology

    Combining agent-based, trait-based and demographic approaches to model coral-community dynamics

    Bruno Sylvain Carturan, Jason Pither ... Lael Parrott
    A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.
    1. Computational and Systems Biology
    2. Ecology

    Data-driven identification of potential Zika virus vectors

    Michelle V Evans, Tad A Dallas ... John M Drake
    Data-driven methods predict over 35 mosquitoes are potential vectors of Zika virus, suggesting a larger geographic area and a greater human population is at risk of infection.
    1. Ecology
    2. Epidemiology and Global Health

    Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C

    Marta S Shocket, Anna B Verwillow ... Erin A Mordecai
    Mechanistic, trait-based models for transmission of West Nile virus and observed incidence of human West Nile disease cases in the US both show optimal transmission at 24-25°C.
    1. Neuroscience

    Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

    Ruben van den Bosch, Frank H Hezemans ... Roshan Cools
    The absence of generally assumed strong correlations between striatal dopamine synthesis capacity and simple indices of working memory capacity, trait impulsivity, and spontaneous eye-blink rate warrants caution for using these traits as proxy measures to replace direct striatal dopamine assessments.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro, Michelle N Yancoskie ... Yingguang Frank Chan
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

    Weichen Song, Yongyong Shi, Guan Ning Lin
    Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
    1. Ecology

    Eco-evolutionary dynamics modulate plant responses to global change depending on plant diversity and species identity

    Peter Dietrich, Jens Schumacher ... Christiane Roscher
    Offspring of plants selected at low and high plant diversity differently respond to global change drivers (nitrogen enrichment, drought), as reflected by their biomass production and trait expression, whereby plant-soil interactions play a significant role in these processes.
    1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio
    Predicting multivariate phenotypic evolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

    Alex N Nguyen Ba, Katherine R Lawrence ... Michael M Desai
    A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.

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