1,769 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

    Michael Chas Sumner et al.
    Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao et al.
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
    1. Microbiology and Infectious Disease

    Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors

    Moirangthem Kiran Singh et al.
    Genetic code expansion (GCE) enables site-specific labeling and visualization of Salmonella secreted effectors, secretion system components and provides a viable alternative for labeling proteins that do not tolerate N- or C-terminal tags.
    1. Structural Biology and Molecular Biophysics

    Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

    Shreyas Bhat et al.
    Subtle differences in handling of intracellular cations can drive macroscopic functional differences in structurally similar monoamine transporters.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle et al.
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Computational and Systems Biology
    2. Medicine

    Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

    Muhammad Arif et al.
    Elucidating widespread and tissue-specific biological process alterations after myocardial infaction in metabolically active tissues using systems biology approaches.
    1. Chromosomes and Gene Expression

    RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry

    Christine E Cucinotta et al.
    Multiple mechanisms, by which a highly conserved chromatin-remodeling factor RSC facilitates initiation and maintenance of large-scale, rapid gene expression upon exit from quiescent state, have been discovered.
    1. Neuroscience

    Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

    Jacob Graves McPherson, Maria F Bandres
    Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei et al.
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Cell Biology
    2. Neuroscience

    Short and long sleeping mutants reveal links between sleep and macroautophagy

    Joseph L Bedont et al.
    Unbiased and targeted genetic approaches reveal a link between sleep and autophagy that could be relevant for sleep function, and for understanding pathological consequences of chronic sleep loss.

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