817 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Tunable protein synthesis by transcript isoforms in human cells

    Stephen N Floor, Jennifer A Doudna
    Measurements of transcript isoform specific translation across the human genome reveal that isoforms from the same gene can differ in protein production by two orders of magnitude.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

    Yoseop Yoon et al.
    Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu et al.
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

    Clotilde Guyon et al.
    The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat et al.
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku et al.
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush et al.
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Neuroscience

    Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

    Saša Jereb et al.
    Differential expression of 3'UTR isoforms expands regulatory and protein diversity in cerebellar Purkinje and granule cells and during granule cell development.
    1. Cell Biology
    2. Neuroscience

    An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus

    Thi-Minh Nguyen et al.
    Interneuron-specific alternative splice variants of the synaptic receptor neurexin are critical for hippocampal network activity and short-term memory.

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