Measurements of transcript isoform specific translation across the human genome reveal that isoforms from the same gene can differ in protein production by two orders of magnitude.

Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.

The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.

ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.

Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.

Gene sharing through different isoforms can precede the formation of independent genes.

Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.

Two myosin 15 isoforms are required separately for the development and long-term maintenance of hearing.

New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.

RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.