A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.
The first-in-class kinase inhibitor, Ibrutinib, destabilizes its autoinhibited Bruton’s tyrosine kinase (BTK) target, and a remote resistance mutation causes global structural changes that activate BTK catalytic activity.
A ClC chloride channel protein allows neurons to interpret both temporal resolution and intensity of sensory input, which thereby contributes to an experience-dependent navigation behavior.
Single somata and dendrites of individual rat neurons were laser-captured and sequenced to discover and compare the subcellular transcriptomes, identifying over 4000 mRNAs in GABAergic dendrites.
Transcriptome and eCLIP analyses in mouse and human reveal splicing factor proline/glutamine rich (SFPQ) as a conserved and critical guardian of long-intron integrity, splicing, and circular RNA (circRNA) production.
In vivo experiments on transgenic mice, and cell culture studies, establish Schwann cell c-Jun as a central regulator of peripheral nerve repair, and repair failure, during aging and chronic denervation.
Skin epithelium can tolerate oncogene-expressing clones through a novel cellular mechanism of inter-clonal competition between renewing progenitors along the clone's edge and differentiating progenitors within the clone's core.
Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
