Large regions of foreign DNA inserted into mammalian chromosomes assemble into H3K9me3-heterochromatin and result in increased condensin loading with organisation into shorter mitotic chromosome loops than endogenous DNA.
The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.