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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

    Bin Z He et al.
    The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
    1. Developmental Biology
    2. Neuroscience

    Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

    Shalini Singh et al.
    Neuronal progenitor cells autonomously inhibit polarization via the transcription factor Zeb1.
    1. Plant Biology

    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module

    Juliana L Matos et al.
    An adult stem-cell lineage terminally differentiates via recruitment of the RETINOBLASTOMA-RELATED protein by a lineage specific transcription factor.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Constitutive auxin response in Physcomitrella reveals complex interactions between Aux/IAA and ARF proteins

    Meirav Lavy et al.
    The auxin-sensitive Aux/IAA transcriptional repressors regulate approximately 35% of the annotated genes in Physcomitrella patens and exhibit complex interactions with both the activating and repressing ARF transcription factors.
    1. Structural Biology and Molecular Biophysics

    The complete structure of the human TFIIH core complex

    Basil J Greber et al.
    The structure of human transcription factor IIH, a critical DNA repair and transcription initiation factor, has been determined by cryo-electron microscopy.
    1. Developmental Biology
    2. Neuroscience

    Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

    Kawssar Harb et al.
    Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
    1. Cancer Biology
    2. Cell Biology

    Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

    Stephin J Vervoort et al.
    Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reproduction: How flies turn food into progeny

    Thomas Flatt
    Sex-optimal diets have different effects on gene expression in female and male flies.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.